Aziz Sancar (born 8 September 1946) is a Turkish-American biochemist and molecular biologist specializing in DNA repair, cell cycle checkpoints, and circadian clock. In 2015, he was awarded the Nobel Prize in Chemistry along with Tomas Lindahl and Paul L. Modrich for their mechanistic studies of DNA repair.

Sancar is currently the Sarah Graham Kenan Professor of Biochemistry and Biophysics at the University of North Carolina School of Medicine and a member of the UNC Lineberger Comprehensive Cancer Center. He is the co-founder of the Aziz & Gwen Sancar Foundation, which is a non-profit organization to promote Turkish culture and to support Turkish students in the United States.